How do I place Framework 16 Macropad into QMK bootloader (flashing) mode?

Welcome to the forum.

There are 3 methods that I can think of for entering bootloader on the macropad, they can be found here

Yeah, Via can be quite annoying like that.

Have you seen the openRGB port a community member made?

If I recall, I think it doesn’t do per-key at the moment. If so, perhaps you could help fix that part.