[RESPONDED] AMD / Fedora 39 reboots when waking from suspend by disconnecting USB mouse

[variegated.vanilla]

I’ll let others chime in because this goes beyond anything I’ve done myself…

That said, some links I came across, to potentially aid your search:
https://wiki.archlinux.org/title/Framework_Laptop_13#Suspend

[Guide] Fedora 36+: Hibernation with enabled secure boot and full disk encryption (fde) decrypting over tpm2

This is a somehow personal step-by-step documentation, how I achieved hibernation and suspend-then-hibernate on a recent Fedora system with enabled secure boot. Basically you patch the kernel to allow hibernation with enabled secure boot and then configure hibernation. This can only be done securely, because we use a swap file stored on an encrypted disk. I used following documentation snippets on the internet: Enable decryption of luks devices with TPM2: Decrypt LUKS volumes with a TPM on Fed…

And if you mean to change back to s2idle…
https://wiki.archlinux.org/title/Power_management/Suspend_and_hibernate#Changing_suspend_method