This has actually been addressed by framework:
There continues to be a lot of incorrect information echoing around the Expansion Bay connector.
We’re developing our own semi-custom connector with the supplier specifically to make it better for end-user handling. The datasheet that people are referencing that states 50 cycles is for an off the shelf connector that Framework Laptop 16 doesn’t ship with.
And they’ve also stated, that they will share cycle life of the actual connector before the laptop ships. (source → Expansion Bay connector durability - #4 by MJ1)