I recently remembered that these type of hubs exist, and while they wouldn’t be usable with the Framework, they did give me an idea.
I am imagining this kind of “dongle” hanging off the side of the laptop, but supported by expansion card prongs. This seems like something I wouldn’t mind leaving plugged into the laptop all the time, and opens up a lot of space for those port-consuming devices, like in my case, a mouse receiver, a YubiKey Nano, and an SD card slot.
Hey, I‘m already working on this. The big problem is charging and DP. There‘s no cheap silicon for this…
One way around expensive silicon is to cheat and not put any in. 
One designed for the right hand side could be made with the rear port directed 90 degrees toward the rear (straight passthrough, like the current USB-C module) with a simple USB 2.0 hub connected to the front port broken out into say, 4 ports? This would allow for a display or power to be connected at an angle away from the mouse hand, while having room for several dongles.