I recently remembered that these type of hubs exist, and while they wouldn’t be usable with the Framework, they did give me an idea.
I am imagining this kind of “dongle” hanging off the side of the laptop, but supported by expansion card prongs. This seems like something I wouldn’t mind leaving plugged into the laptop all the time, and opens up a lot of space for those port-consuming devices, like in my case, a mouse receiver, a YubiKey Nano, and an SD card slot.