Disable NVME drives

Is it possible to disable the nvme drives on the framework 16? I want to be able to install Linux on one drive and windows on the other drive. Is it possible to disable one of the drives in the BIOS so that one OS cannot even see the other drive at all. I know this would require me manually turning it on/off when switching from OS to OS, but this is my ideal scenario.

Use Bitlocker on the Windows drive and LUKS on the Linux drive. Then both drives are encrypted and not accessible to the other OS.

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That would prevent them from accessing each others files. The drives would still be accessible from either side (as in, they can still be overwritten).

You are correct. But just make sure you known which drive is which (Names, Type etc.).
If you disable a drive, you will also have an issue: When a OS is installed or updated, it will scan for other disks and potential OS’s on these and install boot entries for each (usually, dunno about Windows now) so that at the next boot you can choose which OS to boot.
In your use case, you will hit the same issue as described here: Boot Device Issues (Windows 10P / Void Linux)
So - to be honest, know your system, and leave both drives in.
If you are afraid that one OS access the other OS, encrypt the drives (which on a laptop you should do by default).

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I have no issues with this, but perhaps you wanted to address the OP instead?

This is easily addressed by pressing F12 on boot. The bootloader on the drive is intact, and thus the entry will be there in the list, and can easily be booted from there.
I use this method to boot into a recovery drive that i also keep separate from any installed OS. Works every time.

Please understand that I am not the OP, and have no issues whatsoever. I am also not worried about OSes interfering with each other.

I do understand however that some people are not as seasoned in using Linux and Windows on the same system, and would like to keep them on separate drives to ensure that they don’t make accidental mistakes that wipe out the other OS.