My hard drive 2280 has disappeared and is now showing as not connected

I went to start my .NET Framework 16 and found that my secondary hard drive 2280 was not listed in my system. However, when I try to format the hard drives, it appears as connected.

This is a major problem because some of my projects are stored on that drive.

What BIOS version you on?

Can you access the data if mounted externally? What troubleshooting steps have you attempted?