Oculink to Non-eGPU devices should be fine if you use some Oculink Card - It’s what I’m using right now in my setup. The BIOS is haunting me right now as it’s more than just an annoyance. As @Frix_Rioux stated, he’s having to do weird things with the HDMI plug to get his AMD gpu to get a good desktop session. In any case, I should have a solution to this in a couple weeks.
To anyone coming past this, topics discussed in this thread should be considered “Enthusiast” grade. Graphics cards ARE NOT SUPPORTED on Framework desktop and I doubt they will EVER be in an official capacity as the hardware and firmware just isn’t designed for it.