Got Guix installed again and wrestled with my configs for a bit to get my Nix home-manager configuration and my pre-existing Guix config to work together. Had some trouble with my yubikey being seen by GPG for git and ssh but that’s fixed now. KeePassXC still won’t read it without sudo permissions. I’ve fiddled with the udev rules quite a bit by this point so I’m not sure what the issue is, and it’s an issue I’ve had before, in Guix specifically.
The Ath 9462 works pretty well even with linux-libre, all except for bluetooth with is universally nonfunctional for libre or requires some blobs to run, if I’m correct. It’s probably slower than the AX210 chips but for my day to day use it’s unnoticeable.
My Guix config for my framework laptop sits perpetually over here now if anyone wants to reference. Some of my fixes ended up being from my home-manager setup which is in the same repo.
I’ve gone LUKS-less this time. I can’t live without Secure Boot and TPM unlocking anymore 
I may transition back to NixOS pretty quickly and just do a Guix VM. I want to try to get impermanence set up in Guix, but it’ll be a lot of work…