Noticed after upgrading to Fedora 41 beta a while ago that certain apps were slow to open.
Apps such as Files (Nautilus) and terminal would take 3-5 seconds to open.
Compared to a Fedora 40 laptop I have with much older hardware this was bugging me. I waited till Fedora 41 went GA to do more digging.
It seems the fix is to add the following entry to your /etc/environment file:
$ cat /etc/environment
GSK_RENDERER = ngl
Once added, log out then back in, and you should notice that your apps are much more responsive.
I am not 100% sure why this works or is needed - It looks like there is an open bug for this - Default Gnome Apps including Settings will not open when nvidia driver running - but wanted to share for others as well.