Check out this thread: OcuLink eGPU works with the Dual M.2 expansion bay module
A lot of folks in there with various statements on it. I personally run a OCuLink 4i from the dual m.2 adapter and haven’t had any issues with my current configuration.
Framework 16 (7840HS, 32GB DDR4)
Minisforum DEG1 (Radeon RX 6800XT, Silverstone SFX PSU
Fedora 42 KDE
I had been using an Aoostar AG02 instead of the DEG1 but I kept having minor issues. The DEG1 has been more stable, and came with a longer cable (cable compatibility has also been a pain).