I have the same issue. It seems to happen within 10~15 minutes of resuming from sleep. I am running Fedora, and there is nothing that indicates why this is happening in journal or dmesg. Just a complete lock.
Just to confirm - the replacement card also caused lockups. We’ve taken it out and have never once experienced a lock ever since. Maybe co-incidence, but I’m not about to try again.
I had the same issue with total freeze ups with Win11 on 12 gen, but I am not using a DP card. I just started using the mainboard as a desktop with a Dell DA305 adapter for IO. The freezes stopped after I switched to a different hub.