It’s still early times, so there are a kazillion ways to run models on your computer. On Linux, Alpaca, Ramalama, and Newelle are worth a look. Cross-platform apps like LM Studio and OpenWebUI work well too.
NPU and ROCm are basically unsupported on current Framework devices. (the soon-to-be released Desktop is getting ROCm, but at the moment Vulkan is faster). There’s hope on the NPU front: Status of AMD NPU Support - #23 by Dragonfire