The first issue is not a fault of Framework. Over the years, I simply forgot that the cables that plug into the DisplayPorts on the computer side are in fact adapter cables. On the other end are are DVI monitors without native DisplayPort input. This no longer works with the Framework Desktop, except for one output in SVGA resolution before the AMD GPU driver loads (seemingly a fallback mode of the BIOS/firmware).
Today I got official confirmation from Framework that the DisplayPort outputs do not support passive adapter cables (DP++), so my monitors are officially obsolete e-waste.
My second issue is the noisy PSU fan, that turns 100% on / 0% off without the RPM ramp that was promoted in the PSU deep dive on the Framework blog. I’m currently in contact with support about that.