Yep! I’m running Pop!_OS on my Framework
The only issue I had was that I had to set up the fingerprint reader manually, but I’m pretty sure that is true for all distros except Fedora 35. @CJ_Elevated made a great video covering various distros running on the Framework.
There are a few ways to get the fingerprint sensor working. First, there is the install script that CJ made, and those instructions are
Download this install script - http://elevatedsystems.tech/media/scripts/FP_Reader_install.sh
then run
cd ./Downloads
and then
bash ./FP_Reader_install.sh
I did that one just because it was easy and I am very inexperienced in Linux. Another option is to follow @Brett_Kosinski solution found below.