I tried using one of these magnetic USB-C connectors with my Framework, and it did initially work great, but after just a handful of times removing and re-connecting the cable I must have gotten unlucky and damaged some part of the USB-C interface on the Framework mainboard side.
Only the port I was plugging into is affected, but that port no longer works for any USB connections (even USB-A)–it now only works as a power input. Any USB devices are completely ignored.
I don’t necessarily need all 4 ports for USB-C (yet) so I’m willing to accept the damage from my own risk-taking, but I did want to provide anecdotal evidence that there is a very real risk of damaging your mainboard with these connectors.