Disabling Hardware Acceleration in applications that use it (browsers, Discord, Spotify, etc.) seems to be working for me currently. This is of course a remedy and not a fix, but worth trying.
Updating to the december AMD drivers did not work. I’m also running the common 2x16GB Crucial kit, CT2K16G56C46S5. This freezing issue appears to exist with other AMD graphics cards based on threads in other forums, so very reasonable to suspect the graphics drivers.