Given the amount of folks who would like to be able to use 4 USB-C ports without having to use all 4 expansion slots [1], and the power drain problems with some cards, I’d say it would be a good idea to remove the two slots closest to the screen and replace them with 4 fixed USB-C ports. If you space them exactly the same as the mac-books this would allow for re-use of a bunch of mac accessories.
[1]
Dual USB-C Expansion Card Mockup - Creators & Developers / Expansion Card - Framework Community