Yep, this kind of PCB should be possible.
When holding the board with OcuLink port at the same level as the SSD in M.2 port, it looks like the port would need to be mounted upside-down as there’s more clearance that way.
Looking at this picture some more, I think some filing of the lower bezel might be required as the port is too thick to fully be visible.
You can see also that the port would have to sit lower than the base PCB, so a shape like this is the most likely to work:
Although a port there would be pretty wobbly and might require additional retention.
Would have been neater if there wasn’t any PCB where the Framework logo is (marked in red)
Well, maybe an idea for a second revision! Or something @Josh_Cook could address in his design

Could illustrate? I’m not sure I’m getting this fully, sorry
Oooh, nice, thank you, I’ll try that at some point.