@43e I had a similar issue to yours where the keyboard & touchpad/mouse-buttons would randomly stop responding (after initially working). Though it usually only took about 5-10 minutes of use rather than an hour, it could occasionally work for a bit longer.
I don’t know if it would’ve started responding again after 50 seconds, because I’d always immediately close & reopen the laptop - sometimes that would fix it - otherwise, holding the power button until shutoff & rebooting would get it working again (until the next random freeze).
I’m also on a new Framework 16, AMD AI 300, integrated GPU. The issue also affected an external keyboard & mouse (if plugged in) - like the touchpad, the external mouse could still move the pointer after its buttons froze.
Besides the external keyboard & mouse, no other non-Framework hardware was used (external display, eGPU, etc.) - the RAM, SSD, & power supply were all ordered through Framework.
The issue showed up on two different distros, neither of which was Arch-based:
I usually use Linux Mint, but the latest Mint’s based on an Ubuntu LTS that’s too old for the Laptop 16 (24.04), so I first installed one of the Laptop-16’s officially supported distros, Fedora 43, using the spin with Mint’s desktop environment (Cinnamon/X11):
After seeing the keyboard/mouse-button freezes, I replaced the install with Ubuntu 25.10 Cinnamon:
That was also affected, so I tried a third install, vanilla Ubuntu 25.10 (GNOME/Wayland). That completely fixed the issue - it’s still installed, and hasn’t frozen the keyboard/mouse-buttons once.
Assuming we had the same keyboard/mouse-button issue, despite the different distros & desktop environments, the common factor appears to be X11.