Yes. There are two GUIs currently available for QMK, Vial and Via. Both require support to be built into the firmware. Framework is doing support for Via. There is code on their github, and Nrp, the CEO, confirmed it here
If Framework doesn’t also create firmware that supports Vial, the community will probably do it. Vial has more options.
Changing the LED color or pattern will be easy. With Via you will need a Chrome-based browser. You’ll go to https://usevia.app and allow it to connect to your keyboard.
Once someone creates Vial firmware, then we won’t need a browser or internet connection. Vial offers desktop apps for Windows, Linux, and Mac, in addition to a web option at https://vial.rocks.