Yeah…USB peripherals compatibility is, in my experience, flaky with the Framework laptop. There’s been multiple threads of USB devices not connecting / detected, dropping connection…etc.
An early instance / thread:
Even USB sticks (memory) sometimes don’t get connected / detected. Some sticks would drop if there’s heavy read/write activity. I have an ADATA 128GB USB stick…and it would drop in the middle of a large (7GB file) transfer when used with the Framework laptop.
If your mainboard belongs to an early batch of 11th gen, there was the EMI shield sticker issue: