I have the same issue on Ubuntu 21.04 with 5.11.
I’ve just set the default memory sleep to deep, though the issue was happening with the s2idle on suspend as well. In another thread or stackexchange there’s a mention that sleeping again and re-waking, in my case closing and opening the lid again, will fix it.
Here’s some output from preparing to enter sleep with the touchpad not working upon wake:
[ 145.353122] ACPI: Preparing to enter system sleep state S3
[ 145.373108] ACPI: EC: event blocked
[ 145.373109] ACPI: EC: EC stopped
[ 145.373109] PM: Saving platform NVS memory
[ 145.373210] Disabling non-boot CPUs …
[ 145.373796] IRQ 185: no longer affine to CPU1
[ 145.376218] smpboot: CPU 1 is now offline
[ 145.377510] IRQ 187: no longer affine to CPU2
[ 145.378528] smpboot: CPU 2 is now offline
[ 145.380156] IRQ 183: no longer affine to CPU3
[ 145.381212] smpboot: CPU 3 is now offline
[ 145.384469] IRQ 181: no longer affine to CPU4
[ 145.385500] smpboot: CPU 4 is now offline
[ 145.388149] IRQ 40: no longer affine to CPU5
[ 145.388165] IRQ 131: no longer affine to CPU5
[ 145.388183] IRQ 182: no longer affine to CPU5
[ 145.388194] IRQ 186: no longer affine to CPU5
[ 145.389214] smpboot: CPU 5 is now offline
[ 145.390789] IRQ 30: no longer affine to CPU6
[ 145.390798] IRQ 130: no longer affine to CPU6
[ 145.391864] smpboot: CPU 6 is now offline
[ 145.393949] smpboot: CPU 7 is now offline
[ 145.401331] ACPI: Low-level resume complete
[ 145.401609] ACPI: EC: EC started
[ 145.401609] PM: Restoring platform NVS memory
[ 145.404646] Enabling non-boot CPUs …
[ 145.404691] x86: Booting SMP configuration:
[ 145.404692] smpboot: Booting Node 0 Processor 1 APIC 0x2
[ 145.407072] CPU1 is up
[ 145.407103] smpboot: Booting Node 0 Processor 2 APIC 0x4
[ 145.409632] CPU2 is up
[ 145.409657] smpboot: Booting Node 0 Processor 3 APIC 0x6
[ 145.412231] CPU3 is up
[ 145.412253] smpboot: Booting Node 0 Processor 4 APIC 0x1
[ 145.413455] CPU4 is up
[ 145.413478] smpboot: Booting Node 0 Processor 5 APIC 0x3
[ 145.414436] CPU5 is up
[ 145.414457] smpboot: Booting Node 0 Processor 6 APIC 0x5
[ 145.415571] CPU6 is up
[ 145.415591] smpboot: Booting Node 0 Processor 7 APIC 0x7
[ 145.416646] CPU7 is up
[ 145.422025] ACPI: Waking up from system sleep state S3
[ 145.430009] ACPI: EC: interrupt unblocked
[ 145.821957] ACPI: EC: event unblocked
[ 145.954782] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 145.957101] nvme nvme0: 8/0/0 default/read/poll queues
[ 145.975134] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 145.995817] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 146.016967] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 146.038102] i2c_designware i2c_designware.2: timeout waiting for bus ready
When the system wakes from the first sleep, the cursor will move at a far faster rate than it normally does, and it will not click or scroll. Sleeping again will restore the cursor speed, scrolling, and clicking.
[ 158.124946] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 158.145561] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 158.145595] i2c_hid i2c-PIXA3854:00: failed to change power setting.
[ 158.166418] i2c_designware i2c_designware.2: timeout waiting for bus ready
[ 158.687521] i2c_designware i2c_designware.2: timeout in disabling adapter
[ 158.731375] ACPI: EC: interrupt blocked
[ 158.813875] ACPI: Preparing to enter system sleep state S3
[ 158.832184] ACPI: EC: event blocked
[ 158.832185] ACPI: EC: EC stopped
[ 158.832186] PM: Saving platform NVS memory
[ 158.832285] Disabling non-boot CPUs ...
[ 158.835288] smpboot: CPU 1 is now offline
[ 158.837689] smpboot: CPU 2 is now offline
[ 158.842556] smpboot: CPU 3 is now offline
[ 158.845142] smpboot: CPU 4 is now offline
[ 158.848297] smpboot: CPU 5 is now offline
[ 158.850677] smpboot: CPU 6 is now offline
[ 158.853178] smpboot: CPU 7 is now offline
[ 158.860914] ACPI: Low-level resume complete
[ 158.861190] ACPI: EC: EC started
[ 158.861190] PM: Restoring platform NVS memory
[ 158.864181] Enabling non-boot CPUs ...
[ 158.864226] x86: Booting SMP configuration:
[ 158.864226] smpboot: Booting Node 0 Processor 1 APIC 0x2
[ 158.866613] CPU1 is up
[ 158.866642] smpboot: Booting Node 0 Processor 2 APIC 0x4
[ 158.869144] CPU2 is up
[ 158.869167] smpboot: Booting Node 0 Processor 3 APIC 0x6
[ 158.871701] CPU3 is up
[ 158.871722] smpboot: Booting Node 0 Processor 4 APIC 0x1
[ 158.872930] CPU4 is up
[ 158.872954] smpboot: Booting Node 0 Processor 5 APIC 0x3
[ 158.873927] CPU5 is up
[ 158.873948] smpboot: Booting Node 0 Processor 6 APIC 0x5
[ 158.875084] CPU6 is up
[ 158.875103] smpboot: Booting Node 0 Processor 7 APIC 0x7
[ 158.876139] CPU7 is up
[ 158.881506] ACPI: Waking up from system sleep state S3
[ 158.891259] ACPI: EC: interrupt unblocked
[ 159.285256] ACPI: EC: event unblocked
[ 159.415593] nvme nvme0: 8/0/0 default/read/poll queues
[ 159.675964] usb 3-1: reset full-speed USB device number 2 using xhci_hcd
[ 159.816059] ish-hid {33AECD58-B679-4E54-9BD9-A04D34F0C226}: [hid-ish]: enum_devices_done OK, num_hid_devices=1
[ 160.024011] usb 3-9: reset full-speed USB device number 3 using xhci_hcd
[ 160.183558] acpi LNXPOWER:0f: Turning OFF
[ 160.185832] acpi LNXPOWER:0b: Turning OFF
[ 160.186556] acpi LNXPOWER:07: Turning OFF
[ 160.186577] acpi LNXPOWER:06: Turning OFF
[ 160.187313] OOM killer enabled.
[ 160.187313] Restarting tasks ... done.
[ 160.191386] mei_hdcp 0000:00:16.0-b638ab7e-94e2-4ea2-a552-d1c54b627f04: bound 0000:00:02.0 (ops i915_hdcp_component_ops [i915])
[ 160.197980] thermal thermal_zone6: failed to read out thermal zone (-61)
[ 160.200944] PM: suspend exit
Here’s an Arch forum mentioning the same i2c timeouts and touchpad impact - Touchpad suddenly stops working. Only reboot/suspend unfreezes it. / Kernel & Hardware / Arch Linux Forums
Most actual bugs I see in kernel development mailings are in reference to the 4.9-4.11 kernel.