Here’s a couple ideas/+1’s for things already mentioned:
A 10 key number pad that slots into both of the right side expansion card slots, but has 2 (or more?) expansion slots built into it.
A Framework hub/dock/eGPU combo, a separate case that plugs in to one or both expansion card slots on one side. Said case would have, say, 6-8 expansion card slots in it, with a space inside for a separate, upgradable GPU board (and cooling fan), the same way the Mainboard in the laptop itself is replaceable/upgradable. You could start out with just a hub/dock, with multiple monitors (and mixed port types) and additional I/O if you just need additional screen real estate but not necessarily the extra graphics horsepower, but have the ability to add a more powerful GPU later. Or, if the laptop screen is sufficient but you need the GPU power, have the eGPU setup to drive the internal laptop screen, with lots of extra I/O (or extra storage…) available on the hub.
You could also have the expansion slots be taller than on the laptop, for things like full size Ethernet, VGA, multiple USB ports per expansion card, gpio, etc.
It would probably also make sense to have dedicated power going into the hub/eGPU, and power pass-through to run/charge the laptop.
Sorry, this is a lot longer than I thought. Just excited about the laptop itself and all the other possibilities that could go along with it. 
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