For the AMD motherboard, Framework has mentioned that an eGPU will work (link here: Announcing the Framework Laptop 13 powered by AMD Ryzen™ 7040 Series Processors (Really this time)). Depending on its implementation, USB 4 can function identically to Thunderbolt 4 (Thunderbolt is just a certification standard by Intel). Your experience with it will vary depending on what OS and eGPU enclosure you’re using. I use a i5 1240p with a GTX 1080 in a Razer Core X on Windows 11. Sometimes, it immediately picks up when I’ve plugged in the eGPU and will automatically switch over. Other times, I’ll have to enable the eGPU through device manager but overall, it works great.
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