I am seeing or “hearing” an audio delay when I use my framework13 with the WD22TB4 dock. The reason I am using this dock is because I already happen to have it for my WFH dell PC (which btw doesn’t have this issue).
The issue is that when I start playing a video the audio will not be there for 2-3 seconds. Then the audio will “turn on” as if it were on the whole time. This doesn’t happen 100% time but happens pretty often.
I use a WD19TBS, the Thunderbolt 3 variety of the same dock albeit without an onboard audio chip (that’s what the S indicates) and have had no trouble with it on either my original 11th gen Intel or first-gen AMD laptops.
My monitor has an audio output that I plugged my speakers into and it has no startup lag when I begin playing sound. I just selected HDMI/Displayport for the audio output and it worked fine. I run Linux though, not Windows.
Have you tried a different USB audio interface? Have you updated the firmware on the dock?