I’ve been running my i5 DIY on Fedora 35 as a personal daily driver and it’s been flawless.
Remaining minor hardware/“driver” question I haven’t been able to answer yet: Is there any Framework configuration for the lm_sensors package out there?
After running sudo sensors-detect here’s what I get:
$ sensors
coretemp-isa-0000
Adapter: ISA adapter
Package id 0: +43.0°C (high = +100.0°C, crit = +100.0°C)
Core 0: +41.0°C (high = +100.0°C, crit = +100.0°C)
Core 1: +40.0°C (high = +100.0°C, crit = +100.0°C)
Core 2: +38.0°C (high = +100.0°C, crit = +100.0°C)
Core 3: +40.0°C (high = +100.0°C, crit = +100.0°C)
BAT1-acpi-0
Adapter: ACPI interface
in0: 16.39 V
curr1: 550.00 mA
iwlwifi_1-virtual-0
Adapter: Virtual device
temp1: +35.0°C
nvme-pci-0100
Adapter: PCI adapter
Composite: +44.9°C (low = -0.1°C, high = +81.8°C)
(crit = +85.8°C)
acpitz-acpi-0
Adapter: ACPI interface
temp1: +43.8°C (crit = +210.0°C)
I’m pretty sure that last component’s critical temp isn’t 210 degrees C 
Also, I don’t see the fan.
Any ideas? Previously (coming from Thinkpads) the fan would generall just show up in the sensors.
I should mention that I’m still on BIOS 3.02, looking forward to 3.06 on LVFS soon.