It sounds like the mainboard of a Framework is about 230x105mm. That’s just about the footprint (maybe a bit smaller) than most GPUs. Theoretically it seems like you could probably fit them side by side, use the guts of an eGPU enclosure to connect them, and then use the remaining three ports for power and input. Would there be a way to power both the GPU and mainboard with one cord? You’d also have to create a custom case for it and think pretty carefully about cooling, but it seems like you could potentially make something much smaller than most gaming PCs today.
Is that something people might be interested in building?