Contact support and start a ticket with them. I am sure they have had others with a similar issue and have steps to check what is causing it.
You are on the latest BIOS and driver pack. You could try creating another profile/username and try logging in with that and see if the issue persists. It is probably something with the BIOS or the EC that is not recognizing the lid opening, power button pressed, etc. to initiate a wakeup state and bring the laptop back from the sleep states.
Support may have you reset your BIOS to the default settings (I think F5 loads the BIOS optimized defaults). Something is not being communicated to wake the system up from a sleep state.
Usually the issue posted is the Framework Laptop 16 wakes up too often when it is not suppose to wake up! Yours has taken this to the opposite end and just never wakes up!